The KCNH3 Polyclonal Antibody (PAC003700) is a valuable tool for researchers studying the KCNH3 gene, which encodes a member of the voltage-gated potassium channel family. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in various applications such as Western blotting.KCNH3 plays a crucial role in regulating neuronal excitability and has been associated with neurological disorders such as epilepsy and autism. The KCNH3 Polyclonal Antibody binds specifically to the KCNH3 protein, allowing for the detection and analysis of this important channel in different cell types.
Researchers in neuroscience and neurology will find this antibody particularly useful for studying the function and regulation of KCNH3 in normal and diseased states. By understanding the role of KCNH3 in neuronal activity, researchers can potentially uncover novel therapeutic targets for treating neurological conditions.
Antibody Name:
KCNH3 Antibody
Antibody SKU:
PACO03700
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human KCNH3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Kv12.2: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 12q13Cellular Component: integral to plasma membrane; integral to membrane; plasma membraneMolecular Function: protein binding; voltage-gated potassium channel activity; two-component sensor activityBiological Process: synaptic transmission; regulation of membrane potential; two-component signal transduction system (phosphorelay); potassium ion transport
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
