The KCNH3 Polyclonal Antibody (PAC018044) is a valuable tool for researchers studying the KCNH3 gene, which encodes a member of the Kv voltage-gated potassium channel family. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it ideal for Western blotting applications.KCNH3 is involved in regulating membrane potential and neuronal excitability, suggesting its importance in neuronal function and potential implications for neurological disorders.
By targeting the KCNH3 protein, researchers can gain insight into its role in ion channel activity and its potential as a therapeutic target for neurological conditions.With its ability to detect and analyze KCNH3 in various cell types, this antibody is an essential asset for studies focusing on neuroscience, electrophysiology, and drug discovery. By understanding the function of KCNH3, researchers can uncover new pathways for intervention and treatment in neurological diseases.
Antibody Name:
KCNH3 Antibody (PACO18044)
Antibody SKU:
PACO18044
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human KCNH3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18044(KCNH3 Antibody) at dilution 1/12, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Potassium voltage-gated channel subfamily H member 3 is a protein that in humans is encoded by the KCNH3 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit. Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming α subunits that can associate with modulating β subunits. Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus.
Synonyms:
potassium voltage-gated channel, subfamily H (eag-related), member 3
UniProt Protein Function:
Kv12.2: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 12q13Cellular Component: integral to plasma membrane; integral to membrane; plasma membraneMolecular Function: protein binding; voltage-gated potassium channel activity; two-component sensor activityBiological Process: synaptic transmission; regulation of membrane potential; two-component signal transduction system (phosphorelay); potassium ion transport
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
