The KCNH3 Polyclonal Antibody (PAC022514) is a valuable tool for researchers studying the KCNH3 protein, a member of the potassium voltage-gated channel subfamily H. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is ideal for use in Western blot applications. By specifically binding to the KCNH3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a valuable asset for studies in neuroscience, cardiovascular research, and other fields where potassium channels play a role.KCNH3, also known as the ether-a-go-go-related gene 3 (ERG3), is involved in regulating membrane potential and ion flow in cells, impacting processes such as neuronal excitability and cardiac repolarization.
Dysregulation of KCNH3 has been implicated in various disorders, including epilepsy, cardiac arrhythmias, and some types of cancer. By studying the function and expression of KCNH3 using this antibody, researchers can gain valuable insights into its role in health and disease, potentially leading to new therapeutic strategies targeting potassium channels.
Antibody Name:
KCNH3 Antibody (PACO22514)
Antibody SKU:
PACO22514
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from Internal of human KCNH3.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HeLa cells, using KCNH3 antibody.
Background:
Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.
Synonyms:
BEC1; Brain-specific eag-like channel 1; ELK channel 2; ELK2; ether-a-go-go K(+) channel family member
UniProt Protein Function:
Kv12.2: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 12q13Cellular Component: integral to plasma membrane; integral to membrane; plasma membraneMolecular Function: protein binding; voltage-gated potassium channel activity; two-component sensor activityBiological Process: synaptic transmission; regulation of membrane potential; two-component signal transduction system (phosphorelay); potassium ion transport
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
