The KCNH8 Polyclonal Antibody (PAC018045) is a valuable tool for researchers studying the KCNH8 protein, a voltage-gated potassium channel that plays a key role in regulating neuronal excitability and neurotransmitter release. This antibody, produced in rabbits, is highly specific to human KCNH8 samples and has been validated for use in Western blot applications. By binding to the KCNH8 protein, this antibody allows for precise detection and analysis in various cell types, making it an essential component for studies in neuroscience and neuropharmacology.
KCNH8 is involved in modulating action potentials in neurons and is implicated in neurological disorders such as epilepsy, schizophrenia, and bipolar disorder. Understanding the function of KCNH8 is critical for unraveling the mechanisms underlying these conditions and may lead to the development of novel therapeutic strategies. By targeting KCNH8 with this antibody, researchers can further elucidate its role in neuronal function and dysfunction, ultimately paving the way for new insights into neurological diseases.
Antibody Name:
KCNH8 Antibody (PACO18045)
Antibody SKU:
PACO18045
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human KCNH8
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18045(KCNH8 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18045(KCNH8 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit.
Synonyms:
potassium voltage-gated channel, subfamily H (eag-related), member 8
UniProt Protein Function:
KCNH8: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily.Protein type: Membrane protein, integral; Membrane protein, multi-passCellular Component: membrane; integral to plasma membrane; integral to membraneMolecular Function: RNA polymerase II transcription factor activity, enhancer binding; signal transducer activity; voltage-gated potassium channel activity; potassium channel activity; ion channel activity; voltage-gated ion channel activity; two-component sensor activityBiological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; regulation of membrane potential; transport; two-component signal transduction system (phosphorelay); ion transport; signal transduction; transmembrane transport; potassium ion transport; negative regulation of apoptosis
