The KCNH8 Polyclonal Antibody (PAC018046) is a valuable tool for researchers studying the KCNH8 protein, a voltage-gated potassium channel involved in regulating neuronal excitability. This rabbit-derived antibody is highly specific for human samples and has been validated for use in Western blot applications. By targeting the KCNH8 protein, this antibody allows for the detection and analysis of KCNH8 expression in various cell types, making it an ideal choice for studies in neuroscience and neurobiology.KCNH8, also known as Kv12.1, plays a crucial role in controlling the firing patterns of neurons and modulating neurotransmitter release.
Dysregulation of KCNH8 has been linked to neurological disorders such as epilepsy and schizophrenia, making it a promising target for therapeutic interventions. Understanding the function of KCNH8 is essential for unraveling the mechanisms underlying these disorders and developing potential treatment strategies.Overall, the KCNH8 Polyclonal Antibody offers researchers a reliable tool for investigating the role of KCNH8 in neuronal function and dysfunction, with potential implications for the development of novel therapeutics for neurological disorders.
Antibody Name:
KCNH8 Antibody (PACO18046)
Antibody SKU:
PACO18046
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human KCNH8
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18046(KCNH8 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18046(KCNH8 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit.
Synonyms:
potassium voltage-gated channel, subfamily H (eag-related), member 8
UniProt Protein Function:
KCNH8: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily.Protein type: Membrane protein, integral; Membrane protein, multi-passCellular Component: membrane; integral to plasma membrane; integral to membraneMolecular Function: RNA polymerase II transcription factor activity, enhancer binding; signal transducer activity; voltage-gated potassium channel activity; potassium channel activity; ion channel activity; voltage-gated ion channel activity; two-component sensor activityBiological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; regulation of membrane potential; transport; two-component signal transduction system (phosphorelay); ion transport; signal transduction; transmembrane transport; potassium ion transport; negative regulation of apoptosis
