The KCNK13 Polyclonal Antibody (PAC016580) is a valuable tool for researchers studying the KCNK13 protein, also known as Tandem Pore Domain Potassium Channel 13. This antibody, raised in rabbits, is highly specific for human samples and is validated for use in various applications, including Western blot and immunohistochemistry.KCNK13 is a potassium channel protein that plays a crucial role in regulating the electrical activity of cells, particularly in the nervous system. Dysregulation of KCNK13 has been implicated in various neurological disorders and cardiovascular diseases, making it a promising target for therapeutic development.
By using the KCNK13 Polyclonal Antibody, researchers can detect and analyze the expression of KCNK13 in different cell types and tissues, providing insights into its function and potential role in disease pathology. This antibody is a valuable tool for studies in neuroscience, cardiology, and drug discovery related to potassium channel modulation.
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse lung tissue, Primary antibody: PACO16580(KCNK13 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16580(KCNK13 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a potassium channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid, and inhibited by the anesthetic halothane.
Synonyms:
potassium channel, subfamily K, member 13
UniProt Protein Function:
KCNK13: Potassium channel displaying weak inward rectification in symmetrical K(+) solution. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 14q32.11Cellular Component: integral to membrane; plasma membraneMolecular Function: potassium channel activity; voltage-gated ion channel activityBiological Process: synaptic transmission
UniProt Protein Details:
NCBI Summary:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a potassium channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. [provided by RefSeq, Jul 2013]
