The KCNMB3 Polyclonal Antibody (PAC019890) is a powerful tool for studying KCNMB3, a potassium channel subunit that plays a crucial role in regulating cellular excitability. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards KCNMB3 in human samples, making it an excellent choice for Western blotting applications. By binding to KCNMB3, this antibody enables accurate detection and analysis of the protein in a variety of cell types, making it ideal for investigations in neuroscience and cardiovascular research.
KCNMB3 is known for its involvement in the modulation of neuronal excitability and smooth muscle contraction, making it a target of interest in studies related to neurological disorders and cardiovascular diseases. Understanding the functions and regulation of KCNMB3 is key to developing targeted therapies for conditions such as epilepsy, stroke, and hypertension. The KCNMB3 Polyclonal Antibody provides researchers with a reliable tool to explore the role of KCNMB3 in these physiological processes and disease pathways.
Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO19890(KCNMB3 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds.
The image is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19890(KCNMB3 Antibody) at dilution 1/40. (Original magnification: x200).
Background:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming α subunit and the modulatory β subunit. The protein encoded by this gene is an auxiliary β subunit which may partially inactivate or slightly decrease the activation time of MaxiK α subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22.
Synonyms:
potassium large conductance calcium-activated channel, subfamily M β member 3
UniProt Protein Function:
KCNMB3: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 3q26.3-q27Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; plasma membraneMolecular Function: calcium-activated potassium channel activity; potassium channel regulator activityBiological Process: regulation of action potential; synaptic transmission; generation of action potential; detection of calcium ion; blood coagulation; potassium ion transport
UniProt Protein Details:
NCBI Summary:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]
