The KCNMB4 Antibody (PACO19892) is specifically designed for research involving KCNMB4, a potassium channel regulator that plays a key role in controlling smooth muscle tone and neuronal excitability. This polyclonal antibody, generated in rabbits, is highly specific for human samples and has been validated for use in various applications, including Western blotting.KCNMB4 is a critical regulator of potassium channels, which are important for maintaining proper cellular function and communication. Dysregulation of KCNMB4 has been associated with various diseases, including cardiovascular disorders and neurological conditions.
Therefore, studying the expression and function of KCNMB4 is essential for understanding the underlying mechanisms of these diseases and developing potential treatment strategies.With its high reactivity and specificity, the KCNMB4 Antibody (PACO19892) is a valuable tool for researchers studying potassium channel regulation, smooth muscle function, and neuronal excitability. Its ability to bind to the KCNMB4 protein enables accurate detection and analysis, making it an ideal choice for studies in physiology, neurobiology, and cardiovascular research.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19892(KCNMB4 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO19892(KCNMB4 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19892(KCNMB4 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming α subunit and the modulatory β subunit. The protein encoded by this gene is an auxiliary β subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the β 1 subunit.
Synonyms:
potassium large conductance calcium-activated channel, subfamily M, β member 4
UniProt Protein Function:
JARID1B: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cancer Testis Antigen (CTA); Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressorChromosomal Location of Human Ortholog: 1q32.1Cellular Component: cytoplasm; nucleoplasm; nucleusMolecular Function: histone demethylase activity; histone demethylase activity (H3-K4 specific); protein binding; transcription corepressor activity; transcription factor activity
UniProt Protein Details:
NCBI Summary:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]
