The KCNV1 Polyclonal Antibody (PAC063807) is an essential tool for research involving the KCNV1 gene, which encodes a member of the voltage-gated potassium channel family. This antibody, developed in rabbits, is highly specific and reactive with human samples, making it ideal for various experimental applications. With validation for use in Western blotting, this antibody binds specifically to the KCNV1 protein, enabling accurate detection and analysis in a range of cell types. Its reliability and sensitivity make it a valuable asset for studies focused on ion channel function, neuronal excitability, and neurobiology.
The KCNV1 gene product plays a crucial role in regulating the electrical activity of cells, particularly in the nervous system. Dysfunction of KCNV1 has been implicated in neurological disorders such as epilepsy and migraine, making it a promising target for therapeutic intervention. By uncovering the mechanisms underlying KCNV1 function, researchers can contribute to the development of novel treatments for neurological conditions and gain valuable insights into brain biology.
Antibody Name:
KCNV1 Antibody (PACO63807)
Antibody SKU:
PACO63807
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Potassium voltage-gated channel subfamily V member 1 protein (1-200AA)
Immunofluorescence staining of A549 cells with PACO63807 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.
Synonyms:
Potassium voltage-gated channel subfamily V member 1 (Neuronal potassium channel α subunit HNKA) (Voltage-gated potassium channel subunit Kv8.1), KCNV1
UniProt Protein Function:
KCNV1: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 8q23.2Cellular Component: integral component of plasma membrane; plasma membrane; voltage-gated potassium channel complexMolecular Function: ion channel inhibitor activity; potassium channel regulator activity; voltage-gated potassium channel activityBiological Process: potassium ion transport; protein homooligomerization; regulation of molecular function
UniProt Protein Details:
NCBI Summary:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types. [provided by RefSeq, Jul 2008]
