The KCTD7 Polyclonal Antibody (PAC06117) is a valuable tool for researchers studying KCTD7, a protein involved in various cellular processes, including neural development and synaptic transmission. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting KCTD7 in human samples, making it ideal for Western blot applications.KCTD7 is a member of the potassium channel tetramerization domain-containing (KCTD) protein family, known for their role in regulating ion channels and protein ubiquitination. Studies have shown that KCTD7 is essential for proper neuronal function and development, making it a potential target for understanding neurological disorders and brain function.
By using the KCTD7 Polyclonal Antibody, researchers can investigate the role of KCTD7 in various cell types and tissues, providing valuable insights into its function and potential therapeutic implications. This antibody is a valuable tool for studies in neuroscience, neurodevelopmental disorders, and synaptic plasticity, offering new avenues for understanding the complex mechanisms underlying brain function.
Antibody Name:
KCTD7 Antibody (PACO61117)
Antibody SKU:
PACO61117
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human BTB/POZ domain-containing protein KCTD7 protein (5-152AA)
Immunofluorescence staining of A549 cells with PACO61117 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May be involved in the control of excitability of cortical neurons.
Synonyms:
BTB/POZ domain-containing protein KCTD7, KCTD7
UniProt Protein Function:
KCTD7: contains a K+ channel tetramerisation domain (T1) found in voltage-gated K+ channel proteins. Encodes molecular determinants for the assembly of functional tetrameric channels. Two alternatively spliced isoforms have been described.Protein type: Unknown functionChromosomal Location of Human Ortholog: 7q11.21Disease: Epilepsy, Progressive Myoclonic 3, With Or Without Intracellular Inclusions
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the potassium channel tetramerization domain-containing protein family. Family members are identified on a structural basis and contain an amino-terminal domain similar to the T1 domain present in the voltage-gated potassium channel. Mutations in this gene have been associated with progressive myoclonic epilepsy-3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]
