The SFRP2 Polyclonal Antibody is a valuable tool for researchers studying the role of SFRP2, a secreted protein that modulates Wnt signaling pathways and is implicated in various cellular processes, including tissue regeneration, development, and tumorigenesis. This antibody is raised in rabbits and specifically designed for use in Western blotting applications with high reactivity to human samples.SFRP2, also known as Secreted frizzled-related protein 2, is a key player in regulating cell proliferation, migration, and differentiation by modulating Wnt signaling. Dysregulation of SFRP2 expression has been linked to various diseases, including cancer, fibrosis, and cardiovascular disorders.
By targeting SFRP2, researchers can better understand its role in disease pathogenesis and potentially develop novel therapeutic strategies.With its strong reactivity and specificity, the SFRP2 Polyclonal Antibody enables precise detection and analysis of SFRP2 in various cell types, making it an ideal tool for studies in cell biology, molecular biology, and oncology. By using this antibody, researchers can gain insights into the function of SFRP2 and its implications in disease development, paving the way for advancements in diagnostic and therapeutic approaches.
Product Name:
[KD Validated] SFRP2 Polyclonal Antibody
SKU:
CAB22017
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SFRP2 (NP_003004.1).
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.
Purification Method:
Affinity purification
Gene ID:
6423
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts from wild type(WT) and SFRP2 knockdown (KD) HeLa cells, using SFRP2 antibody (CAB22017) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
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