The KDM2B Antibody (CAB16017) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications. By binding to the KDM2B protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in epigenetics, gene regulation, and cancer research.KDM2B, also known as FBXL10, plays a crucial role in chromatin remodeling and gene expression by removing methyl groups from histone proteins. Dysregulation of KDM2B has been implicated in various diseases, including cancer, developmental disorders, and neurological conditions.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
KDM2B Antibody
SKU:
CAB16017
Size:
20μL, 100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
CXXC2, Fbl10, PCCX2, FBXL10, JHDM1B, KDM2B
Positive Sample:
HeLa, HepG2
Cellular Localization:
Nucleolus, Nucleoplasm, Nucleus.
Calculated MW:
153kDa
Observed MW:
153kDa
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.
Purification Method
Affinity purification
Gene ID
84678
RRID
AB_2763453
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using KDM2B Rabbit pAb (CAB16017) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 90s.
