The KDM4C Antibody (CAB8485) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody is raised in rabbits and exhibits high reactivity with human samples, specifically recognizing the KDM4C protein in Western blot applications.KDM4C, also known as JHDM3C, plays a crucial role in epigenetic regulation by removing methyl groups from histone proteins, thereby influencing gene expression. Dysregulation of KDM4C has been implicated in various diseases, including cancer and neurodevelopmental disorders. Understanding the function of KDM4C through the use of this antibody is essential for unraveling its role in these pathologies and identifying potential therapeutic targets.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
KDM4C Antibody
SKU:
CAB8485
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
GASC1, JHDM3C, JMJD2C, TDRD14C, KDM4C
Positive Sample:
Mouse brain
Cellular Localization:
Nucleus.
Calculated MW:
120kDa
Observed MW:
120kDa
This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
23081
RRID
AB_2770070
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from Mouse brain, using KDM4C Rabbit pAb (CAB8485) at 1:800 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 60s.
