The KDSR Polyclonal Antibody (PACO10077) is a valuable tool for researchers studying the KDSR protein, a key enzyme involved in sphingolipid metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and is well-suited for use in Western blot applications. By targeting the KDSR protein, this antibody enables researchers to detect and analyze KDSR levels in various cell types, making it ideal for investigations in lipid metabolism, cell signaling, and cancer research.KDSR, also known as 3-ketodihydrosphingosine reductase, plays a critical role in the biosynthesis of sphingolipids, which are important components of cell membranes and signaling molecules.
Dysregulation of KDSR has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Understanding the function of KDSR is essential for developing targeted therapies that modulate sphingolipid metabolism in these pathological conditions.Overall, the PACO10077 antibody offers researchers a valuable tool for investigating the role of KDSR in cellular processes and disease pathogenesis, ultimately advancing our understanding of sphingolipid metabolism and its implications for human health.
The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008]
