The KIAA0319L Polyclonal Antibody (PACO37850) is a valuable tool for researchers studying the KIAA0319L protein, which plays a role in brain development and is associated with dyslexia and other neurodevelopmental disorders. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.KIAA0319L is known to be involved in neuronal migration and synaptic plasticity, making it a key player in the formation of neural circuits and cognitive functions. Research on KIAA0319L is important for understanding the molecular mechanisms underlying developmental disorders and may lead to the development of new therapies for conditions such as dyslexia.
The KIAA0319L Polyclonal Antibody enables the detection and analysis of KIAA0319L expression in different cell types and tissues, making it a versatile tool for studies in neuroscience and neurodevelopmental biology. By studying the role of KIAA0319L in brain development, researchers can gain insights into the pathophysiology of neurodevelopmental disorders and potentially identify novel therapeutic targets.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO37850 at dilution of 1:100.
Immunofluorescent analysis of A549 cells using PACO37850 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Possible role in axon guidance through interaction with RTN4R.
Synonyms:
Dyslexia-associated protein KIAA0319-like protein (Adeno-associated virus receptor) (AAVR), KIAA0319L, AAVR KIAA1837
UniProt Protein Function:
KIAA0319L: protein of unknown function.Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1p34.2Cellular Component: cytoplasmic vesicle; integral to membraneMolecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
This gene is a candidate gene for dyslexia susceptibility.[provided by RefSeq, Apr 2009]
