Description
KIDINS220 Antibody (PACO10091)
The Kidins220 Polyclonal Antibody (PACO10091) is a specialized research tool designed for the study of Kidins220, a protein essential for neuronal development and function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Kidins220, also known as ankyrin repeat-rich membrane spanning protein or ARMS, plays a crucial role in various neuronal processes, including neuronal differentiation, survival, and signaling. By targeting the Kidins220 protein, researchers can gain insights into the mechanisms underlying neurodevelopmental disorders, neurodegenerative diseases, and psychiatric conditions.
This antibody enables the detection and analysis of Kidins220 in a variety of cell types, making it an invaluable tool for studies in neuroscience and neurobiology. By understanding the functions and regulatory roles of Kidins220, researchers may uncover new therapeutic targets for neurological conditions and contribute to the development of novel treatments.
| Antibody Name: | KIDINS220 Antibody (PACO10091) |
| Antibody SKU: | PACO10091 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human KIDINS220 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | kinase D-interacting substrate, 220kDa;KIDINS220;ARMS;MGC163482 ; |
| UniProt Protein Function: | KIDINS220: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin- mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Protein kinase, regulatory subunit Chromosomal Location of Human Ortholog: 2p24 Cellular Component: nucleoplasm; protein complex; membrane; late endosome; integral to membrane; cytosol Molecular Function:PDZ domain binding Biological Process: activation of MAPKK activity; nerve growth factor receptor signaling pathway; in utero embryonic development; dendrite morphogenesis; cytoplasmic transport |
| UniProt Code: | Q9ULH0 |
| NCBI GenInfo Identifier: | 172044825 |
| NCBI Gene ID: | 57498 |
| NCBI Accession: | Q9ULH0.3 |
| UniProt Secondary Accession: | Q9ULH0,Q4VC08, Q6MZU2, Q9H889, Q9H9E4, Q9NT37, Q9UF42 A1L4N4, |
| UniProt Related Accession: | Q9ULH0 |
| Molecular Weight: | 1771 |
| NCBI Full Name: | Kinase D-interacting substrate of 220 kDa |
| NCBI Synonym Full Names: | kinase D-interacting substrate, 220kDa |
| NCBI Official Symbol: | KIDINS220Â Â |
| NCBI Official Synonym Symbols: | ARMSÂ Â |
| NCBI Protein Information: | kinase D-interacting substrate of 220 kDa; truncated KIDINS220; ankyrin repeat-rich membrane spanning; ankyrin repeat-rich membrane-spanning protein |
| UniProt Protein Name: | Kinase D-interacting substrate of 220 kDa |
| UniProt Synonym Protein Names: | Ankyrin repeat-rich membrane-spanning protein |
| Protein Family: | Kinase D-interacting substrate |
| UniProt Gene Name: | KIDINS220Â Â |
| UniProt Entry Name: | KDIS_HUMAN |
