The KIR3DL2 Polyclonal Antibody (CAB10117) is a valuable tool for researchers studying KIR3DL2, a cell surface receptor involved in immune regulation. This antibody is produced in rabbits and is highly specific to human samples, making it ideal for use in Western blot applications. By binding to the KIR3DL2 protein, researchers can accurately detect and analyze its expression in various cell types.
KIR3DL2 is known for its role in regulating immune responses and has been implicated in diseases such as cancer and autoimmune disorders. By studying the activity of KIR3DL2, researchers can gain insight into potential therapeutic targets for these conditions. This antibody is a crucial tool for those interested in exploring the role of KIR3DL2 in immunology and cancer research.
Product Name:
KIR3DL2 Rabbit Polyclonal Antibody
SKU:
CAB10117
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 361-455 of human KIR3DL2 (NP_006728.2).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
50kDa
Observed MW:
50kDa
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
3812
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KIR3DL2 antibody (CAB10117) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
