The KLHL2 Polyclonal Antibody (PAC016593) is specially designed for research involving KLHL2, a protein involved in the regulation of cell growth and proliferation. The antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the KLHL2 protein, this antibody enables accurate detection and analysis in various cell types, making it a valuable tool for studies in molecular biology and cancer research.KLHL2 is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex and plays a crucial role in the degradation of target proteins through the ubiquitin-proteasome pathway.
Understanding the functions and mechanisms of KLHL2 is essential for elucidating its role in regulating cell proliferation and tumor development. By investigating KLHL2, researchers can uncover novel insights into the molecular pathways underlying cancer progression and potentially identify new therapeutic targets for cancer treatment.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO16593(KLHL2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 6%SDS-PAGE, Lysate: 100 μg, Lane 1-2: Jurkat cells, K562 cells, Primary antibody: PACO16593(KLHL2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16593(KLHL2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
KLHL2 (kelch-like protein 2), also known as actin-binding protein Mayven, is a 593 amino acid, actin-binding protein. Highly expressed in brain, KLHL2 is thought to play a role in the organization of the actin cytoskeleton in brain cells.
Synonyms:
kelch-like family member 2
UniProt Protein Function:
KLHL2: May play a role in organizing the actin cytoskeleton of the brain cells. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Chromosomal Location of Human Ortholog: 4q21.2
Cellular Component: actin cytoskeleton; cytoplasm
Molecular Function:actin binding; protein binding; ubiquitin-protein ligase activity
