The KLHL2 Polyclonal Antibody (PACO16594) is a valuable tool for researchers studying KLHL2, a protein involved in various cellular processes such as protein degradation and cell cycle regulation. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the KLHL2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential asset for studies in cell biology and disease research.KLHL2 is known for its role in the ubiquitin-proteasome system, where it acts as a substrate-specific adaptor protein for the Cullin 3-based E3 ubiquitin ligase complex.
This function is crucial for maintaining cellular homeostasis and regulating protein turnover. Research on KLHL2 has implications in understanding diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases, where dysregulation of protein degradation processes can contribute to pathogenesis. By elucidating the mechanisms of KLHL2 action, researchers can uncover potential therapeutic targets for these conditions.
Antibody Name:
KLHL2 Antibody (PACO16594)
Antibody SKU:
PACO16594
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human KLHL2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16594(KLHL2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16594(KLHL2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
KLHL2 (kelch-like protein 2), also known as actin-binding protein Mayven, is a 593 amino acid, actin-binding protein. Highly expressed in brain, KLHL2 is thought to play a role in the organization of the actin cytoskeleton in brain cells.
Synonyms:
kelch-like family member 2
UniProt Protein Function:
KLHL2: May play a role in organizing the actin cytoskeleton of the brain cells. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Chromosomal Location of Human Ortholog: 4q21.2
Cellular Component: actin cytoskeleton; cytoplasm
Molecular Function:actin binding; protein binding; ubiquitin-protein ligase activity
