Description
KLHL2 Antibody (PACO27809)
The KLHL2 Polyclonal Antibody (PAC027809) is a valuable tool for research involving KLHL2, a protein involved in various cellular processes such as protein degradation and cell growth regulation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By detecting and binding to the KLHL2 protein, researchers can analyze its expression and activity in different cell types, making it ideal for studies in molecular biology and cancer research.
KLHL2 is known to play a crucial role in protein ubiquitination and degradation, as well as in the regulation of cell cycle progression and growth control. Its involvement in these processes makes it a potential target for understanding diseases such as cancer and neurodegenerative disorders. Studying the functions of KLHL2 can provide valuable insights into possible therapeutic interventions that target protein degradation pathways or cell growth signaling.
| Antibody Name: | KLHL2 Antibody (PACO27809) |
| Antibody SKU: | PACO27809 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Kelch-like protein 2 protein (1-155AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot Positive WB detected in: Jurkat whole cell lysate, Mouse liver tissue All lanes: KLHL2 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 66, 67, 57 kDa Observed band size: 66, 67 kDa . |
 | Immunofluorescent analysis of Hela cells using PACO27809 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO27809 at dilution of 1:100. |
| Background: | Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors. |
| Synonyms: | Kelch-like protein 2 (Actin-binding protein Mayven), KLHL2 |
| UniProt Protein Function: | KLHL2: May play a role in organizing the actin cytoskeleton of the brain cells. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4q21.2 Cellular Component: actin cytoskeleton; cytoplasm Molecular Function:actin binding; protein binding; ubiquitin-protein ligase activity Biological Process: protein ubiquitination |
| UniProt Code: | O95198 |
| NCBI GenInfo Identifier: | 52788227 |
| NCBI Gene ID: | 11275 |
| NCBI Accession: | O95198.2 |
| UniProt Secondary Accession: | O95198,Q8N484, Q8TBH5, A6NCM7, B2RD18, B4DFH7, F5H6M3 |
| UniProt Related Accession: | O95198 |
| Molecular Weight: | 56,086 Da |
| NCBI Full Name: | Kelch-like protein 2 |
| NCBI Synonym Full Names: | kelch like family member 2 |
| NCBI Official Symbol: | KLHL2Â Â |
| NCBI Official Synonym Symbols: | MAV; MAYVEN; ABP-KELCHÂ Â |
| NCBI Protein Information: | kelch-like protein 2 |
| UniProt Protein Name: | Kelch-like protein 2 |
| UniProt Synonym Protein Names: | Actin-binding protein Mayven |
| Protein Family: | Kelch-like protein |
| UniProt Gene Name: | KLHL2Â Â |
| UniProt Entry Name: | KLHL2_HUMAN |
| Antibodies |
| KLHL2 Antibody (PACO10133) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
