The KLHL4 Polyclonal Antibody (PACO10141) is a valuable tool for researchers studying the KLHL4 protein, known for its role in cell cycle regulation and cytoskeletal organization. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blotting. By binding to the KLHL4 protein, this antibody allows for the detection and analysis of KLHL4 in different cell types, making it ideal for investigations in cell biology and cancer research.
KLHL4 is a member of the Kelch-like family of proteins, which have been implicated in diverse cellular processes such as protein degradation, cell signaling, and cytoskeletal dynamics. Understanding the function of KLHL4 is crucial for unraveling its potential contributions to diseases like cancer and neurodegenerative disorders. By targeting KLHL4 with this antibody, researchers can further elucidate its role in these contexts and potentially identify new therapeutic targets for future treatments.
KLHL4: 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: Xq21.3Cellular Component: cytoplasmMolecular Function: ubiquitin-protein ligase activity
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the kelch family of proteins, which are characterized by kelch repeat motifs and a POZ/BTB protein-binding domain. It is thought that kelch repeats are actin binding domains. However, the specific function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
