The KLRF1 Polyclonal Antibody (PAC019914) is a valuable tool for researchers studying the cell surface molecule KLRF1, which is involved in immune regulation and inhibiting immune responses. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.KLRF1, also known as killer cell lectin-like receptor F1, is a key player in immune homeostasis and has been implicated in various disease states, including cancer, autoimmune disorders, and chronic inflammatory conditions.
By targeting KLRF1 with this antibody, researchers can detect and analyze the protein in different cell types, making it an ideal tool for studies in immunology and cancer research.Understanding the role of KLRF1 in immune modulation is essential for the development of targeted therapies that can manipulate immune function for therapeutic purposes. By utilizing the KLRF1 Polyclonal Antibody, researchers can gain valuable insights into the function of this important immune regulator and its potential implications for disease treatment.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19914(KLRF1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human bladder carcinoma tissue, Primary antibody: PACO19914(KLRF1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19914(KLRF1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release
Synonyms:
killer cell lectin-like receptor subfamily F, member 1
UniProt Protein Function:
KLRF1: Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Receptor, misc.; Membrane protein, integralChromosomal Location of Human Ortholog: 12p13.31Cellular Component: membrane; integral to plasma membraneMolecular Function: transmembrane receptor activity; MHC class I receptor activity; carbohydrate bindingBiological Process: cell surface receptor linked signal transduction
UniProt Protein Details:
NCBI Summary:
KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]
