The KRT72 Polyclonal Antibody (PAC03590) is a valuable tool for researchers studying KRT72, a member of the keratin family of proteins involved in maintaining the structural integrity of epithelial cells. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting KRT72 in human samples, making it suitable for use in immunohistochemistry and Western blotting applications.KRT72 is expressed in the hair follicle and plays a crucial role in hair growth and development.
Aberrant expression of KRT72 has been implicated in hair disorders and diseases such as alopecia, making it a promising target for research in dermatology and regenerative medicine. By using the KRT72 Polyclonal Antibody, researchers can further explore the functions and regulatory mechanisms of KRT72 in normal and pathological conditions, advancing our understanding of hair biology and potential therapeutic interventions.
Antibody Name:
KRT72 Antibody (PACO35590)
Antibody SKU:
PACO35590
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human
Immunogen:
Recombinant Human Keratin, type II cytoskeletal 72 protein (301-511AA)
Western blot. All lanes: KRT72 antibody at 2µg/ml + MCF-7 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 56, 52 kDa. Observed band size: 56, 52 kDa.
Background:
Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).
Synonyms:
Keratin, type II cytoskeletal 72 (Cytokeratin-72) (CK-72) (Keratin-72) (K72) (Type II inner root sheath-specific keratin-K6irs2) (Type-II keratin Kb35), KRT72, K6IRS2 KB35 KRT6 KRT6IRS2
UniProt Protein Function:
KRT72: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). Belongs to the intermediate filament family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 12q13.13Cellular Component: keratin filamentMolecular Function: structural molecule activity
UniProt Protein Details:
NCBI Summary:
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells. The type II keratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This gene encodes a type II keratin that is specifically expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q12-q13. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2009]
