The LAMC3 Polyclonal Antibody (PACO02311) is a valuable tool for researchers studying LAMC3, a key component of laminin-332, an extracellular matrix protein involved in cell adhesion and migration. This antibody, produced in rabbits, is highly specific to human samples and is ideal for use in Western blot applications. By targeting the LAMC3 protein, this antibody allows for the detection and analysis of LAMC3 expression in various cell types, making it essential for studies in cancer biology and tissue development.LAMC3, a member of the laminin family, plays a crucial role in promoting cell adhesion and migration, processes that are fundamental to tissue organization and wound healing.
Dysregulation of LAMC3 expression has been linked to various diseases, including cancer and developmental disorders. Investigating the function of LAMC3 can provide valuable insights into the mechanisms underlying these conditions and may lead to the development of targeted therapies. The LAMC3 Polyclonal Antibody is a reliable tool for researchers seeking to explore the role of LAMC3 in health and disease.
Antibody Name:
LAMC3 Antibody
Antibody SKU:
PACO02311
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC, IF
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human Laminin gamma-3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
LAMC3: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMC3 are the cause of cortical malformations occipital (OCCM). OCCM is a disease in which affected individuals develop seizures, sometimes associated with transient visual changes. Brain MRI shows both pachygyria and polymicrogyria restricted to the lateral occipital lobes.Protein type: Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 9q34.12Cellular Component: basement membrane; extracellular region; membrane; proteinaceous extracellular matrixMolecular Function: structural molecule activityBiological Process: astrocyte development; cell adhesion; cellular morphogenesis during differentiation; extracellular matrix organization and biogenesis; retina development in camera-type eye; visual perceptionDisease: Cortical Malformations, Occipital
UniProt Protein Details:
NCBI Summary:
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 3. The gamma 3 chain is most similar to the gamma 1 chain, and contains all the 6 domains expected of the gamma chain. It is a component of laminin 12. The gamma 3 chain is broadly expressed in skin, heart, lung, and the reproductive tracts. In skin, it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration. Gamma 3 is also a prominent element of the apical surface of ciliated epithelial cells of lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. [provided by RefSeq, Aug 2011]
