The LARS2 Polyclonal Antibody (PACO10198) is a valuable tool for researchers studying LARS2, a mitochondrial leucyl-tRNA synthetase involved in protein synthesis. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the LARS2 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for investigations in the fields of biochemistry and molecular biology.
LARS2 plays a crucial role in protein translation within mitochondria, making it essential for cellular function and metabolism. Dysregulation of LARS2 has been linked to various metabolic disorders and neurodegenerative diseases, highlighting its importance in human health. The LARS2 Polyclonal Antibody provides researchers with a reliable tool for studying the expression and function of LARS2, ultimately advancing our understanding of mitochondrial biology and related pathologies.
LARS2: a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq, Jul 2008]Protein type: Translation; Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Mitochondrial; Ligase; EC 6.1.1.4Chromosomal Location of Human Ortholog: 3p21.3Cellular Component: mitochondrion; mitochondrial matrix; cytosolMolecular Function: leucine-tRNA ligase activity; ATP bindingBiological Process: leucyl-tRNA aminoacylation; tRNA aminoacylation for protein translation; regulation of translational fidelity; gene expressionDisease: Perrault Syndrome 4
UniProt Protein Details:
NCBI Summary:
This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq, Jul 2008]
