Description
LAT2 Antibody (PACO10202)
The LAT2 Polyclonal Antibody (PACO10202) is a valuable tool for researchers studying LAT2, a transmembrane protein involved in T cell activation and immune response. This antibody, produced in rabbits, is highly specific for detecting LAT2 in human samples and is validated for use in Western blot applications. By binding to LAT2, the antibody enables researchers to analyze and monitor LAT2 expression in different cell types, making it an essential tool for studies in immunology and cancer research.LAT2, also known as linker for activation of T cells 2, plays a crucial role in T cell signaling and activation, making it a key target for understanding immune responses and diseases related to T cell dysfunction.
By investigating the function of LAT2, researchers can gain insights into the mechanisms underlying immune regulation and potentially develop novel therapeutic strategies for immune-related disorders.Overall, the LAT2 Polyclonal Antibody is a reliable reagent for exploring the role of LAT2 in immune modulation and disease pathogenesis, providing valuable information for advancing our understanding of immune function and potential therapeutic interventions.
| Antibody Name: | LAT2 Antibody (PACO10202) |
| Antibody SKU: | PACO10202 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Human LAT2 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | linker for activation of T cells family, member 2;LAT2;HSPC046;LAB;NTAL;WBSCR15;WBSCR5;WSCR5 ; |
| UniProt Protein Function: | LAB: linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: mast cell granule; integral to membrane; plasma membrane; lipid raft Molecular Function:protein binding; SH2 domain binding Biological Process: B cell receptor signaling pathway; B cell activation; calcium-mediated signaling; innate immune response; mast cell degranulation |
| NCBI Summary: | This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9GZY6 |
| NCBI GenInfo Identifier: | 74752543 |
| NCBI Gene ID: | 7462 |
| NCBI Accession: | Q9GZY6.1 |
| UniProt Secondary Accession: | Q9GZY6,Q9BXX8, Q9NZY9, A6NFK6, A8K209, A8K4F1, D3DXF9 |
| UniProt Related Accession: | Q9GZY6 |
| Molecular Weight: | 12,255 Da |
| NCBI Full Name: | Linker for activation of T-cells family member 2 |
| NCBI Synonym Full Names: | linker for activation of T cells family, member 2 |
| NCBI Official Symbol: | LAT2Â Â |
| NCBI Official Synonym Symbols: | LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15Â Â |
| NCBI Protein Information: | linker for activation of T-cells family member 2; non-T-cell activation linker; linker for activation of B-cells; membrane-associated adapter molecule; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosomal region 15 protein; linker for activation of T cells, transmembrane adaptor 2 |
| UniProt Protein Name: | Linker for activation of T-cells family member 2 |
| UniProt Synonym Protein Names: | Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein |
| Protein Family: | Linker for activation of T-cells family |
| UniProt Gene Name: | LAT2Â Â |
| UniProt Entry Name: | NTAL_HUMAN |
