The Lamin B Receptor Polyclonal Antibody (CAB5468) is a valuable tool for researchers studying the Lamin B Receptor protein, which plays a key role in nuclear envelope structure and function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.The Lamin B Receptor is involved in nuclear envelope assembly and stability, as well as in regulating chromatin organization and gene expression. Dysregulation of this protein has been linked to various diseases, including cancer and laminopathies.
By targeting the Lamin B Receptor with this antibody, researchers can investigate its role in cellular processes and disease pathology.This antibody is essential for studies in cell biology, cancer biology, and genetic disorders, providing a reliable tool for detecting and analyzing the Lamin B Receptor in various experimental settings. Its specificity and sensitivity make it a crucial component for researchers looking to unravel the intricate functions of this protein and its implications in health and disease.
Product Name:
LBR Rabbit Polyclonal Antibody
SKU:
CAB5468
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-211 of human LBR (NP_002287.2).
The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
Purification Method:
Affinity purification
Gene ID:
3930
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using LBR antibody (CAB5468) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
