The LONP1 Polyclonal Antibody (CAB4293) is a valuable tool for researchers studying LONP1, a key protein involved in mitochondrial quality control and regulation of cell death. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the LONP1 protein, this antibody enables researchers to detect and analyze protein levels in a variety of cell types, making it an essential tool for studies in mitochondrial biology and cell death pathways.LONP1, a member of the AAA+ family of ATPases, plays a crucial role in maintaining mitochondrial function by degrading misfolded proteins and promoting mitochondrial proteostasis.
Dysregulation of LONP1 has been implicated in various diseases, including neurodegenerative disorders and cancer, making it a promising target for therapeutic intervention. By understanding the function and regulation of LONP1, researchers can gain insights into the molecular mechanisms underlying mitochondrial dysfunction and develop novel strategies for treating associated diseases.
Product Name:
LONP1 Rabbit Polyclonal Antibody
SKU:
CAB4293
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 120-400 of human LONP1 (NP_004784.2).
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9361
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using LONP1 Rabbit pAb (CAB4293) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
