The LRP1 Monoclonal Antibody (CAB0633) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. It binds to the LRP1 protein, enabling accurate detection and analysis in a variety of cell types, making it an essential tool for studies in cardiovascular disease, neurodegenerative disorders, and cancer research.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
LRP1 Monoclonal Antibody
SKU:
CAB0633
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC0275
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
U-87MG, Mouse lung, Mouse liver, Mouse brain, Rat lung, Rat liver, Rat brain
Cellular Localization:
Cell Membrane, Cytoplasm, Extracellular Side, Membrane, Nucleus, Peripheral Membrane Protein, Single-Pass Type I Membrane Protein, Coated Pit.
Calculated MW:
505kDa
Observed MW:
85kDa
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.
Purification Method
Affinity purification
Gene ID
4035
RRID
AB_2861470
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using LRP1 Rabbit mAb (CAB0633) at 1:5000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 5s.
