The LRP6 Polyclonal Antibody (CAB15070) is specifically designed for researchers studying the LRP6 protein, a crucial mediator of the Wnt signaling pathway. This antibody is raised in rabbits and has been validated for use in Western blot applications, allowing for the detection and analysis of LRP6 in various cell types.LRP6 is known for its role in cell proliferation, differentiation, and migration, making it a key player in developmental processes and tumorigenesis. Its dysregulation has been linked to various diseases, including cancer and neurodegenerative disorders, making it an attractive target for therapeutic interventions.
By using the LRP6 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of the LRP6 protein, ultimately leading to a better understanding of its implications in health and disease. This antibody is an essential tool for studies in cell biology, developmental biology, and cancer research.
Product Name:
LRP6 Rabbit Polyclonal Antibody
SKU:
CAB15070
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human LRP6 (NP_002327.2).
Endoplasmic reticulum, Membrane, Single-pass type I membrane protein.
Calculated MW:
180kDa
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
Purification Method:
Affinity purification
Gene ID:
4040
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using LRP6 antibody (CAB15070) at dilution of 1:100. Blue: DAPI for nuclear staining.
