Description
LTB Antibody (PACO20722)
The LTB Antibody (PAC020722) is a highly specific and reliable tool for researchers studying LTB, a protein involved in inflammatory responses and immune regulation. This polyclonal antibody is produced in rabbits and has been extensively validated for use in various experimental applications, including Western blotting. LTB, also known as lymphotoxin beta, is a crucial mediator of immune responses and plays a key role in inflammation and immune cell activation. By targeting LTB with this antibody, researchers can gain valuable insights into the function of this protein in different cell types and biological processes.
With its high reactivity and specificity for human samples, the LTB Antibody is an essential tool for studies in immunology, inflammation, and cancer research. By enabling the detection and analysis of LTB protein expression, this antibody helps advance our understanding of the mechanisms underlying immune-related diseases and opens up new possibilities for therapeutic interventions.
| Antibody Name: | LTB Antibody (PACO20722) |
| Antibody SKU: | PACO20722 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:30-1:150 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human LTB |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20722(LTB Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Lymphotoxin β is a type II membrane protein of the TNF family. It anchors lymphotoxin-α to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-α 1/β 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-β receptor. The minor complex is lymphotoxin-α 2/β 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-β isoform b is unable to complex with lymphotoxin-α suggesting a function for lymphotoxin-β which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Synonyms: | lymphotoxin β (TNF superfamily, member 3) |
| UniProt Protein Function: | LTB: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: extracellular space; integral to membrane Molecular Function:cytokine activity; tumor necrosis factor receptor binding; receptor binding Biological Process: skin development; positive regulation of interleukin-12 biosynthetic process; cell-cell signaling; gene expression; immune response; signal transduction; lymph node development |
| NCBI Summary: | Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q06643 |
| NCBI GenInfo Identifier: | 4505035 |
| NCBI Gene ID: | 4050 |
| NCBI Accession: | NP_002332.1 |
| UniProt Related Accession: | Q06643 |
| Molecular Weight: | ~ 25kDa |
| NCBI Full Name: | lymphotoxin-beta isoform a |
| NCBI Synonym Full Names: | lymphotoxin beta |
| NCBI Official Symbol: | LTBÂ Â |
| NCBI Official Synonym Symbols: | p33; TNFC; TNFSF3; TNLG1CÂ Â |
| NCBI Protein Information: | lymphotoxin-beta |
| UniProt Protein Name: | Lymphotoxin-beta |
| UniProt Synonym Protein Names: | Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3 |
| UniProt Gene Name: | LTBÂ Â |
| UniProt Entry Name: | TNFC_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
