The LYL1 Antibody (PAC021729) is a polyclonal antibody specifically designed for research involving LYL1, a transcription factor crucial for the regulation of hematopoiesis and leukemogenesis. The antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blot and immunofluorescence.LYL1 is known for its role in the development of blood cells and its dysregulation is associated with various types of leukemia and other hematologic malignancies.
By targeting LYL1, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.This antibody enables the specific detection and analysis of LYL1 protein in different cell types, making it an invaluable tool for studies in hematology and cancer research. Understanding the function of LYL1 is essential for advancing our knowledge of hematopoiesis and developing targeted therapies for leukemia and other blood disorders.
Antibody Name:
LYL1 Antibody (PACO21729)
Antibody SKU:
PACO21729
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human Lyl-1.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen The MGC Project Team, Genome Res. 14:2121-2127(2004).
Clonality:
Polyclonal
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Lyl-1 antibody.
Synonyms:
Protein lyl-1; Lymphoblastic leukemia-derived sequence 1; LYL1;
UniProt Protein Function:
LYL1: A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.Protein type: Transcription factor; DNA-binding; OncoproteinChromosomal Location of Human Ortholog: 19p13.2Cellular Component: nucleusMolecular Function: DNA binding; protein bindingBiological Process: B cell differentiation; blood vessel maturation; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
This gene represents a basic helix-loop-helix transcription factor. The encoded protein may play roles in blood vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Sep 2010]
