The LZTFL1 Polyclonal Antibody (PACO16640) is a valuable tool for researchers studying LZTFL1, a protein involved in intracellular trafficking and ciliogenesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is recommended for use in Western blot experiments. By binding to LZTFL1, the antibody enables visualization and analysis of the protein in various cell types, making it a versatile option for investigations in cell biology and molecular biology.LZTFL1 plays a crucial role in regulating the formation and function of primary cilia, which are important organelles involved in signal transduction and cellular communication.
Dysregulation of cilia has been linked to various developmental disorders and diseases, making LZTFL1 a promising target for research in these areas. By understanding the function and regulation of LZTFL1, researchers can gain insights into cilia-related processes and potential therapeutic strategies for related conditions.
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Human transitional cell carcinoma tissue, 293T cells, A172 cells, human testis tissue, Hela cells, Primary antibody: PACO16640(LZTFL1 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO16640(LZTFL1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants.
Synonyms:
leucine zipper transcription factor-like 1
UniProt Protein Function:
LZTFL1: Belongs to the LZTFL1 family.Chromosomal Location of Human Ortholog: 3p21.3Cellular Component: cytosolMolecular Function: identical protein binding; protein binding; protein complex bindingDisease: Bardet-biedl Syndrome 17
UniProt Protein Details:
NCBI Summary:
This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2013]
