The LZTFL1 Polyclonal Antibody (PAC016641) is a valuable tool for researchers studying LZTFL1, a protein involved in ciliary trafficking and assembly. This antibody, produced in rabbits, exhibits high specificity and reactivity with LZTFL1 in human samples, making it an ideal choice for Western blot applications. By binding to LZTFL1, this antibody allows for the detection and analysis of the protein in various cell types, providing insights into its role in ciliary function and potential implications in diseases related to ciliary dysfunction.
LZTFL1, also known as leucine zipper transcription factor-like 1, is a key player in the regulation of ciliary biology, which is essential for various cellular processes such as signal transduction and sensory function. Dysregulation of ciliary function has been linked to multiple disorders, including ciliopathies and certain types of cancer. Therefore, investigating the function of LZTFL1 using this antibody can contribute to a better understanding of ciliary biology and its implications in disease pathogenesis.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16641(LZTFL1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human testis tissue, 293T cells, A172 cells, Primary antibody: PACO16641(LZTFL1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16641(LZTFL1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants.
Synonyms:
leucine zipper transcription factor-like 1
UniProt Protein Function:
LZTFL1: Belongs to the LZTFL1 family.Chromosomal Location of Human Ortholog: 3p21.3Cellular Component: cytosolMolecular Function: identical protein binding; protein binding; protein complex bindingDisease: Bardet-biedl Syndrome 17
UniProt Protein Details:
NCBI Summary:
This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2013]
