The MAGEA10 Monoclonal Antibody (PAC016642) is a powerful tool for researchers studying MAGEA10, a cancer/testis antigen overexpressed in various tumor types. This antibody, produced using recombinant technology, exhibits high specificity and sensitivity for detecting MAGEA10 in human samples, making it ideal for applications such as immunohistochemistry and flow cytometry.MAGEA10 is a member of the MAGEA family of antigens, which are known for their involvement in tumorigenesis and cancer progression.
As a promising target for cancer therapy, MAGEA10 has the potential to revolutionize personalized treatment strategies and improve patient outcomes. By using the MAGEA10 Monoclonal Antibody, researchers can gain valuable insights into the expression patterns and functions of MAGEA10 in cancer cells, paving the way for innovative therapeutic approaches in the fight against cancer.
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A375 cells, Primary antibody: PACO16642(MAGEA10 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO16642(MAGEA10 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants.
Synonyms:
melanoma antigen family A, 10
UniProt Protein Function:
MAGE-A10: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.Chromosomal Location of Human Ortholog: Xq28Cellular Component: nucleus
UniProt Protein Details:
NCBI Summary:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding the same protein have been found for this gene. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq]
