The MAGEB18 Polyclonal Antibody (PAC019973) is a valuable tool for researchers studying MAGEB18, a member of the MAGE family of cancer/testis antigens. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By targeting the MAGEB18 protein, this antibody allows for the detection and analysis of MAGEB18 expression in various cell types, making it ideal for studies in cancer research and immunology.
MAGEB18 is known to be involved in tumorigenesis and has been implicated in promoting cancer progression. Its unique expression pattern in cancer cells makes it an attractive target for developing targeted therapies for cancer treatment. Research into the function and regulation of MAGEB18 is essential for understanding its role in cancer development and for identifying potential therapeutic strategies that could effectively target this antigen.
Antibody Name:
MAGEB18 Antibody (PACO19973)
Antibody SKU:
PACO19973
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human MAGEB18
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19973(MAGEB18 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO19973(MAGEB18 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors and, based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens that are expressed in tumors of different histologic types and in normal testis and placenta. MAGE-B18 (melanoma-associated antigen B18) is a 343 amino acid, protein that contains one MAGE domain and may be involved in tumorigenesis. The gene encoding MAGE-B18 maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes.
