The MAGE-B2 Polyclonal Antibody (PACO10340) is a key tool for researchers studying MAGE-B2, a member of the MAGE family of cancer-testis antigens. This antibody, produced in rabbits, shows high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to the MAGE-B2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in cancer biology and immunotherapy research.MAGE-B2 is known for its involvement in tumorigenesis and its potential as a target for cancer therapy.
Its expression has been observed in various types of cancer, making it a promising candidate for targeted treatments. Understanding the function of MAGE-B2 is crucial for developing effective strategies for cancer diagnosis and treatment. The MAGE-B2 Polyclonal Antibody provides researchers with a valuable tool for investigating the role of MAGE-B2 in cancer progression and developing novel therapeutic approaches.
melanoma antigen family B, 2;MAGEB2;CT3.2;DAM6;MAGE-XP-2;MGC26438 ;
UniProt Protein Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
UniProt Protein Details:
NCBI Summary:
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]
