The Magel2 Polyclonal Antibody (PAC01981) is a valuable tool for researchers studying Magel2, a protein associated with Prader-Willi syndrome and involved in neurodevelopmental processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various research applications, including Western blotting.Magel2 is known for its role in regulating circadian rhythm and energy balance, making it a promising target for investigations into conditions such as obesity and sleep disorders.
By detecting and analyzing Magel2 protein expression in different cell types, this antibody aids in expanding our understanding of its function and potential implications in disease pathology.The versatility of the Magel2 Polyclonal Antibody makes it an indispensable tool for researchers exploring the molecular mechanisms underlying neurological disorders and metabolic diseases. Its specificity and reliability ensure accurate and reproducible results, contributing to advancements in the fields of genetics and neurobiology.
Antibody Name:
MAGEL2 Antibody (PACO19981)
Antibody SKU:
PACO19981
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human MAGEL2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19981(MAGEL2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS.
Synonyms:
MAGE-like 2
UniProt Protein Function:
MAGE-L2: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Interacts with TRIM27Chromosomal Location of Human Ortholog: 15q11.2Cellular Component: retromer complex; early endosome; nucleus; endosomeMolecular Function: protein binding; ubiquitin-protein ligase activityBiological Process: transcription, DNA-dependent; rhythmic process; negative regulation of transcription, DNA-dependent; regulation of circadian rhythm; retrograde transport, endosome to GolgiDisease: Prader-willi Syndrome; Prader-willi-like Syndrome
