The MAP1A Polyclonal Antibody (PACO18951) is a valuable tool for researchers studying the microtubule-associated protein 1A (MAP1A), a key player in neuronal development and function. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the MAP1A protein, this antibody allows for precise detection and analysis in various cell types, making it ideal for investigations in neuroscience and neurodegenerative diseases.MAP1A is crucial for maintaining the structure and function of microtubules in neurons, essential for processes like axonal transport and synaptic plasticity.
Dysregulation of MAP1A has been linked to neurodevelopmental disorders, neurodegenerative diseases, and cognitive impairments. Understanding the role of MAP1A is essential for advancing therapies that target these conditions and improve overall brain health. The MAP1A Polyclonal Antibody is a valuable tool for researchers seeking to unravel the complexities of MAP1A function and its implications in neurological disorders.
Antibody Name:
MAP1A Antibody (PACO18951)
Antibody SKU:
PACO18951
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human MAP1A
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18951(MAP1A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18951(MAP1A Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development.
Synonyms:
microtubule-associated protein 1A
UniProt Protein Function:
MAP1A: structural protein involved in the filamentous cross- bridging between microtubules and other skeletal elements. Various serine residues may be phosphorylated by PKA.Protein type: Motility/polarity/chemotaxis; CytoskeletalChromosomal Location of Human Ortholog: 15q15.3Cellular Component: microtubule; microtubule associated complex; cytosolMolecular Function: protein binding; microtubule binding; structural molecule activityBiological Process: sensory perception of sound; microtubule cytoskeleton organization and biogenesis
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008]
