The MAP3K6 Polyclonal Antibody (PACO05678) is a crucial tool for researchers studying the MAP3K6 protein, a key regulator of cell signaling pathways involved in various biological processes. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples and is validated for Western blot applications. By targeting the MAP3K6 protein, researchers can investigate its role in cell growth, differentiation, and apoptosis in different cell types.MAP3K6, also known as transforming growth factor-beta-activated kinase 1 (TAK1), is a critical mediator of immune responses and cellular stress signaling.
Its involvement in inflammatory pathways and its regulation of cell survival and death processes make it a promising target for research in immunology, cancer biology, and neurodegenerative diseases. Understanding the function of MAP3K6 is essential for developing targeted therapeutic strategies aimed at modulating these signaling pathways for treating various diseases.
Antibody Name:
MAP3K6 Antibody (PACO05678)
Antibody SKU:
PACO05678
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:5000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from the Internal region of human MEK Kinase-6.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
MEKK6: a member of the STE11 protein kinase family. Activates JNK, but not ERK or p38. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Protein type: Protein kinase, STE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; STE group; STE11 familyChromosomal Location of Human Ortholog: 1p36.11Molecular Function: ATP binding; magnesium ion binding; MAP kinase kinase kinase activityBiological Process: activation of JNK activity; protein amino acid phosphorylation; signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
