The MAP4K1 Polyclonal Antibody (PACO00935) is a valuable tool for researchers studying the MAP4K1 protein, an important kinase involved in various cellular processes, including cell growth and immune response regulation. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications. By binding to MAP4K1, the antibody enables precise detection and analysis of this protein in different cell types, making it an ideal choice for studies in immunology, cancer research, and beyond.MAP4K1, also known as mitogen-activated protein kinase kinase kinase kinase 1, is a key player in signaling pathways that control cell proliferation, survival, and differentiation.
Its dysregulation has been linked to diseases such as cancer, autoimmune disorders, and inflammatory conditions. By deciphering the functions of MAP4K1, researchers can gain insights into the underlying mechanisms of these diseases and potentially identify new therapeutic targets for intervention.Overall, the MAP4K1 Polyclonal Antibody serves as a reliable tool for investigating the role of MAP4K1 in cellular pathways and disease processes, ultimately contributing to the advancement of biomedical research and the development of innovative treatment strategies.
Antibody Name:
MAP4K1 Antibody
Antibody SKU:
PACO00935
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human HPK1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
HPK1: a protein kinase of the STE20 family. Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. May play a role in hematopoietic lineage decisions and growth regulation. Positively regulated by PGE2 and a negative regulator of PGE2-induced FOS gene transcription. Protein type: Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; STE group; STE20 family; KHS subfamilyChromosomal Location of Human Ortholog: 19q13.1-q13.4Cellular Component: cytoplasm; membraneMolecular Function: ATP binding; MAP kinase kinase kinase kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activityBiological Process: activation of JNK activity; activation of MAPKKK activity; cell proliferation; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; response to stress
