The MARC1 Polyclonal Antibody (PACO19229) is a vital tool for researchers studying the MARC1 protein, a key player in oxidative stress response and mitochondrial function. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications. By binding to the MARC1 protein, researchers can effectively detect and analyze its expression in various cell types, facilitating investigations in the fields of biochemistry and metabolism.MARC1, also known as mitochondrial amidoxime reducing component 1, is crucial for maintaining redox balance within the cell and is involved in the metabolism of purines and other molecules.
Its role in regulating energy production and oxidative stress response makes it a promising target for research into metabolic diseases, neurodegenerative disorders, and aging-related conditions. Studying the function of MARC1 is essential for unraveling its impact on cellular health and developing therapeutic strategies to address related pathologies.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19229(MARC1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human normal liver tissue, Primary antibody: PACO19229(MARC1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19229(MARC1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
MOSC1 (MOCO sulphurase C-terminal domain containing 1), also known as MARC1, is a 337 amino acid, mitochondrial protein that is thought to function as an oxidoreductase. Existing as three alternatively spliced isoforms, MOSC1 contains one MOSC domain and binds molybdenum as a cofactor. The gene encoding MOSC1 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, ParkinsonÂ’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
Synonyms:
mitochondrial amidoxime reducing component 1
UniProt Protein Function:
MOSC1: As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.-.-.-; Oxidoreductase; MitochondrialChromosomal Location of Human Ortholog: 1q41Cellular Component: mitochondrionMolecular Function: molybdenum ion binding; molybdopterin cofactor binding; nitrate reductase activityBiological Process: nitrate metabolic process
