The MARC1 Polyclonal Antibody (PACO19230) is a valuable tool for researchers studying the MARC1 protein, a key player in cellular metabolism and antioxidant defense mechanisms. This antibody, produced in rabbits, shows high specificity and sensitivity for detecting MARC1 in human samples, making it ideal for use in Western blot assays.MARC1, also known as mitochondrial amidoxime reducing component 1, is involved in the regulation of oxidative stress and energy metabolism within cells. Its functions are crucial for maintaining cellular homeostasis and protecting against oxidative damage, making it a promising target for investigating metabolic disorders and oxidative stress-related diseases.
By using the MARC1 Polyclonal Antibody, researchers can gain insights into the role of MARC1 in cellular pathways and disease processes, paving the way for the development of potential therapeutic interventions targeting MARC1 in conditions such as metabolic syndrome, diabetes, and neurodegenerative disorders. This antibody is a valuable tool for advancing research in the fields of metabolism, redox biology, and disease mechanisms.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19230(MARC1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: HepG2 cells, Primary antibody: PACO19230(MARC1 Antibody) at dilution 1/1400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19230(MARC1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
MOSC1 (MOCO sulphurase C-terminal domain containing 1), also known as MARC1, is a 337 amino acid, mitochondrial protein that is thought to function as an oxidoreductase. Existing as three alternatively spliced isoforms, MOSC1 contains one MOSC domain and binds molybdenum as a cofactor. The gene encoding MOSC1 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.
Synonyms:
mitochondrial amidoxime reducing component 1
UniProt Protein Function:
MOSC1: As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.-.-.-; Oxidoreductase; MitochondrialChromosomal Location of Human Ortholog: 1q41Cellular Component: mitochondrionMolecular Function: molybdenum ion binding; molybdopterin cofactor binding; nitrate reductase activityBiological Process: nitrate metabolic process
