The MC2R Polyclonal Antibody (CAB3010) is a valuable tool for researchers studying the Melanocortin 2 Receptor (MC2R), a crucial component of the melanocortin signaling pathway that regulates various physiological processes including steroidogenesis. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the MC2R protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in endocrinology and hormone-related disorders.
The MC2R receptor, also known as ACTH receptor, plays a vital role in the stimulation of cortisol production in the adrenal cortex, making it a key player in the body's stress response and metabolism regulation. Dysregulation of the MC2R signaling pathway has been linked to various conditions such as adrenal insufficiency and Cushing's syndrome, making it an important target for research in endocrine disorders and adrenal function. Understanding the function and regulation of MC2R is essential for developing targeted therapies and treatment strategies for these disorders.
Product Name:
MC2R Rabbit Polyclonal Antibody
SKU:
CAB3010
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human MC2R (NP_000520.1)
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4158
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MC2R Rabbit pAb (CAB3010) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
