Description
MECR Antibody (PACO42106)
The MECR Polyclonal Antibody (PAC042106) is a valuable tool for research involving MECR, a key enzyme involved in mitochondrial fatty acid synthesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the MECR protein, this antibody enables accurate detection and analysis in various cellular contexts, making it an essential asset for studies in biochemistry and metabolic research.
MECR, also known as mitochondrial enoyl-CoA reductase, is crucial for maintaining lipid metabolism and energy production in mitochondria. Dysregulation of MECR has been implicated in metabolic disorders and diseases such as metabolic syndrome, diabetes, and neurodegenerative conditions. By investigating the role of MECR in these pathways, researchers can gain valuable insights into potential therapeutic targets for managing these conditions and improving metabolic health.
| Antibody Name: | MECR Antibody (PACO42106) |
| Antibody SKU: | PACO42106 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Rat |
| Immunogen: | Recombinant Human Trans-2-enoyl-CoA reductase, mitochondrial protein (211-373AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat heart tissue. All lanes: MECR antibody at 3.3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 41, 33 kDa. Observed band size: 41 kDa. |
 | Immunohistochemistry analysis of human liver cancer using PACO42106 at dilution of 1:100. |
| Background: | Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid, synthesis. |
| Synonyms: | Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC 1.3.1.104) (2-enoyl thioester reductase) (Nuclear receptor-binding factor 1) (HsNrbf-1) (NRBF-1), MECR, NBRF1 |
| UniProt Protein Function: | MECR: Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial synthesis of fatty acids. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - fatty acid elongation in mitochondria; Oxidoreductase; EC 1.3.1.38 Chromosomal Location of Human Ortholog: 1p35.3 Cellular Component: mitochondrion; nucleus Molecular Function:zinc ion binding; trans-2-enoyl-CoA reductase (NADPH) activity Biological Process: fatty acid metabolic process; fatty acid biosynthetic process |
| UniProt Code: | Q9BV79 |
| NCBI GenInfo Identifier: | 334302832 |
| NCBI Gene ID: | 51102 |
| NCBI Accession: | Q9BV79.2 |
| UniProt Secondary Accession: | Q9BV79,Q5SYU0, Q5SYU1, Q5SYU2, Q6IBU9, Q9Y373, B3KT72 |
| UniProt Related Accession: | Q9BV79 |
| Molecular Weight: | 373 |
| NCBI Full Name: | Trans-2-enoyl-CoA reductase, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial trans-2-enoyl-CoA reductase |
| NCBI Official Symbol: | MECRÂ Â |
| NCBI Official Synonym Symbols: | NRBF1; CGI-63; FASN2BÂ Â |
| NCBI Protein Information: | trans-2-enoyl-CoA reductase, mitochondrial; nuclear receptor binding factor 1; mitochondrial 2-enoyl thioester reductase; homolog of yeast 2-enoyl thioester reductase |
| UniProt Protein Name: | Trans-2-enoyl-CoA reductase, mitochondrial |
| UniProt Synonym Protein Names: | Nuclear receptor-binding factor 1; HsNrbf-1; NRBF-1 |
| UniProt Gene Name: | MECRÂ Â |
| UniProt Entry Name: | MECR_HUMAN |
| Antibodies |
| MECR Antibody (PACO10436) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
