Description
MERTK/TYRO3 Antibody (PACO02320)
The MERTK Tyro3 Antibody (PACO02320) is a valuable tool for researchers studying the MERTK and Tyro3 proteins, both of which are receptor tyrosine kinases with significant roles in cell signaling pathways. This polyclonal antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blot analysis. These receptors are involved in regulating processes such as cell proliferation, differentiation, and phagocytosis, making them important targets for research in the fields of immunology and cancer biology.
By detecting and analyzing the MERTK and Tyro3 proteins in different cell types, this antibody enables researchers to gain insights into their functions and potential implications in diseases such as cancer and autoimmune disorders.Understanding the activity of MERTK and Tyro3 can provide valuable information for the development of targeted therapies that modulate cell signaling pathways and potentially impact disease progression. The MERTK Tyro3 Antibody (PACO02320) is a reliable tool for investigating the functions of these important receptors in various research settings.
| Antibody Name: | MERTK/TYRO3 Antibody |
| Antibody SKU: | PACO02320 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from human MerTK/Tyro3 around the non-phosphorylation site of Y749/681. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | MERTK; MER; Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; TYRO3; BYK; DTK; RSE; SKY; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kin |
| UniProt Protein Function: | Mer: a proto-oncogene receptor tyrosine-protein kinase of the Axl family. Binds several ligands including LGALS3, Tubby, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Oncoprotein; Kinase, protein; TK group; Axl family Chromosomal Location of Human Ortholog: 2q14.1 Cellular Component: extracellular space; photoreceptor outer segment; integral to plasma membrane; cytoplasm; plasma membrane Molecular Function:protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: platelet activation; negative regulation of lymphocyte activation; peptidyl-tyrosine phosphorylation; vagina development; protein amino acid phosphorylation; phagocytosis; cell surface receptor linked signal transduction; cell-cell signaling; retina development in camera-type eye; natural killer cell differentiation; positive regulation of phagocytosis; protein kinase B signaling cascade; spermatogenesis; blood coagulation; leukocyte migration; apoptotic cell clearance; secretion by cell Disease: Retinitis Pigmentosa 38 |
| NCBI Summary: | This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q12866 |
| NCBI GenInfo Identifier: | 160332297 |
| NCBI Gene ID: | 10461 |
| NCBI Accession: | Q12866.2 |
| UniProt Secondary Accession: | Q12866,Q9HBB4, |
| UniProt Related Accession: | Q12866 |
| Molecular Weight: | 999 |
| NCBI Full Name: | Tyrosine-protein kinase Mer |
| NCBI Synonym Full Names: | MER proto-oncogene, tyrosine kinase |
| NCBI Official Symbol: | MERTKÂ Â |
| NCBI Official Synonym Symbols: | MER; RP38; c-Eyk; c-mer; Tyro12Â Â |
| NCBI Protein Information: | tyrosine-protein kinase Mer; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MerTK; c-mer proto-oncogene tyrosine kinase |
| UniProt Protein Name: | Tyrosine-protein kinase Mer |
| UniProt Synonym Protein Names: | Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK |
| Protein Family: | Tyrosine-protein kinase |
| UniProt Gene Name: | MERTKÂ Â |
| UniProt Entry Name: | MERTK_HUMAN |
