Description
MINK1 Antibody (PACO01065)
The MINK1 Polyclonal Antibody (PACO01065) is a valuable tool for researchers studying the MINK1 protein, involved in cell signaling pathways and regulation of cellular processes. This antibody, raised in rabbits, specifically targets human samples and has been validated for use in Western blot applications.MINK1, a serine/threonine kinase, plays a crucial role in cellular functions such as cell proliferation, survival, and cytoskeletal organization. Its dysregulation has been linked to various diseases, including cancer and neurological disorders. By detecting and analyzing MINK1 protein levels in different cell types, this antibody aids in understanding the mechanisms underlying these conditions, making it a valuable asset in both basic research and drug development efforts.
The MINK1 Polyclonal Antibody provides researchers with a reliable tool for investigating the functions and dysregulation of the MINK1 protein, offering insights into potential therapeutic targets and mechanisms for various diseases. Its specificity and sensitivity make it a valuable addition to studies focusing on cell signaling pathways and regulatory mechanisms.
| Antibody Name: | MINK1 Antibody |
| Antibody SKU: | PACO01065 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the Internal region of human MINK1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | MINK1; B55; MAP4K6; MINK; YSK2; ZC3; Misshapen-like kinase 1; GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6 |
| UniProt Protein Function: | MINK: a protein kinase of the STE20 family. Studies of the mouse ortholog indicate increased expression during postnatal mouse cerebral development. Activates JNK and the p38 pathways. Three splicing isoforms have been described. |
| UniProt Protein Details: | Protein type:EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; MSN subfamily Chromosomal Location of Human Ortholog: 17p13.2 Cellular Component: axon; cell junction; cytoplasm; cytosol; dendrite; Golgi apparatus; postsynaptic density; postsynaptic membrane Molecular Function:ATP binding; MAP kinase kinase kinase kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity Biological Process: actin cytoskeleton reorganization; dendrite morphogenesis; JNK cascade; microvillus biogenesis; multicellular organismal development; negative thymic T cell selection; neurite morphogenesis; positive regulation of JNK cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of cell migration; regulation of cell-cell adhesion; regulation of cell-matrix adhesion; regulation of mitotic cell cycle; response to stress; synaptic transmission |
| NCBI Summary: | This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016] |
| UniProt Code: | Q8N4C8 |
| NCBI GenInfo Identifier: | 296437370 |
| NCBI Gene ID: | 50488 |
| NCBI Accession: | Q8N4C8.2 |
| UniProt Secondary Accession: | Q8N4C8,Q5U8Z0, Q9P1X1, Q9P2R8, D3DTK3, D3DTK4, |
| UniProt Related Accession: | Q8N4C8 |
| Molecular Weight: | 143,637 Da |
| NCBI Full Name: | Misshapen-like kinase 1 |
| NCBI Synonym Full Names: | misshapen like kinase 1 |
| NCBI Official Symbol: | MINK1Â Â |
| NCBI Official Synonym Symbols: | B55; ZC3; MINK; YSK2; MAP4K6Â Â |
| NCBI Protein Information: | misshapen-like kinase 1 |
| UniProt Protein Name: | Misshapen-like kinase 1 |
| UniProt Synonym Protein Names: | GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6 |
| Protein Family: | Misshapen-like kinase |
| UniProt Gene Name: | MINK1Â Â |
| UniProt Entry Name: | MINK1_HUMAN |
