Description
MINK1 Antibody (PACO10496)
The MINK1 Polyclonal Antibody (PAC010496) is a valuable tool for researchers studying the MINK1 protein, a kinase involved in cellular signaling pathways. This antibody, derived from rabbit immunizations, exhibits high reactivity with human samples and is optimized for Western blot applications. By specifically binding to the MINK1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in cell signaling, molecular biology, and cancer research.
MINK1, also known as misshapen-like kinase 1, plays a crucial role in regulating cell growth, proliferation, and migration through its involvement in various signaling cascades. Its significance in cellular processes makes it a valuable target for research into cancer, cardiovascular diseases, and developmental disorders. Understanding the function of MINK1 is essential for uncovering its role in disease progression and identifying potential therapeutic targets for intervention.
| Antibody Name: | MINK1 Antibody (PACO10496) |
| Antibody SKU: | PACO10496 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human MINK1 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | misshapen-like kinase 1 (zebrafish);MINK1;B55;MAP4K6;MGC21111;MINK;YSK2;ZC3;hMINK;hMINKβ ; |
| UniProt Protein Function: | MINK: a protein kinase of the STE20 family. Studies of the mouse ortholog indicate increased expression during postnatal mouse cerebral development. Activates JNK and the p38 pathways. Three splicing isoforms have been described. |
| UniProt Protein Details: | Protein type:EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; MSN subfamily Chromosomal Location of Human Ortholog: 17p13.2 Cellular Component: axon; cell junction; cytoplasm; cytosol; dendrite; Golgi apparatus; postsynaptic density; postsynaptic membrane Molecular Function:ATP binding; MAP kinase kinase kinase kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity Biological Process: actin cytoskeleton reorganization; dendrite morphogenesis; JNK cascade; microvillus biogenesis; multicellular organismal development; negative thymic T cell selection; neurite morphogenesis; positive regulation of JNK cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of cell migration; regulation of cell-cell adhesion; regulation of cell-matrix adhesion; regulation of mitotic cell cycle; response to stress; synaptic transmission |
| NCBI Summary: | This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016] |
| UniProt Code: | Q8N4C8 |
| NCBI GenInfo Identifier: | 296437370 |
| NCBI Gene ID: | 50488 |
| NCBI Accession: | Q8N4C8.2 |
| UniProt Secondary Accession: | Q8N4C8,Q5U8Z0, Q9P1X1, Q9P2R8, D3DTK3, D3DTK4, |
| UniProt Related Accession: | Q8N4C8 |
| Molecular Weight: | 143,637 Da |
| NCBI Full Name: | Misshapen-like kinase 1 |
| NCBI Synonym Full Names: | misshapen like kinase 1 |
| NCBI Official Symbol: | MINK1Â Â |
| NCBI Official Synonym Symbols: | B55; ZC3; MINK; YSK2; MAP4K6Â Â |
| NCBI Protein Information: | misshapen-like kinase 1 |
| UniProt Protein Name: | Misshapen-like kinase 1 |
| UniProt Synonym Protein Names: | GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6 |
| Protein Family: | Misshapen-like kinase |
| UniProt Gene Name: | MINK1Â Â |
| UniProt Entry Name: | MINK1_HUMAN |
