The MLLT4 Polyclonal Antibody (CAB18865) is a valuable tool for researchers studying MLLT4, a protein involved in chromosomal translocations and gene fusions in leukemia. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications.MLLT4, also known as AF5q31, is a transcriptional coregulator that plays a critical role in hematopoietic development and leukemogenesis. Its involvement in gene rearrangements associated with leukemia makes it a key target for therapeutic research.
By detecting and analyzing MLLT4 expression in various cell types, this antibody is ideal for investigations in oncology and hematology.Understanding the function and regulation of MLLT4 is essential for developing targeted therapies for leukemia and other hematologic malignancies. With its specificity and reliability, the MLLT4 Polyclonal Antibody is a valuable tool for researchers aiming to unravel the complexities of MLLT4-related diseases.
Product Name:
MLLT4 Rabbit Polyclonal Antibody
SKU:
CAB18865
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1510-1680 of human MLLT4 (NP_001353249.1).
This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.
Purification Method:
Affinity purification
Gene ID:
4301
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MLLT4 Rabbit pAb (CAB18865) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
