The MMP1 Monoclonal Antibody (CAB22080) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated through mouse hybridoma technology, offers high specificity and sensitivity for detecting MMP-1 in a variety of samples.MMP-1, also known as collagenase-1, plays a crucial role in degrading collagen in the extracellular matrix, contributing to processes such as wound healing, tissue repair, and angiogenesis. Dysregulation of MMP-1 activity has been implicated in a range of diseases, including arthritis, cancer, and cardiovascular disorders.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
MMP1 Monoclonal Antibody
SKU:
CAB22080
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC55239
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Purification Method
Affinity purification
Gene ID
4312
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using MMP1 Rabbit mAb (CAB22080) at1:66000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
Western blot analysis of various lysates using MMP1 Rabbit mAb (CAB22080) at1:66000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
